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Why Fentanyl is More Addictive Than Heroin | The Science of the Opioid Crisis
Fentanyl has become the deadliest drug in modern history, but what exactly makes it so much more dangerous and addictive than heroin? In this video, we explore the molecular science and physiological impacts that set fentanyl apart.

In this video, we cover:
Molecular Potency: Why fentanyl is 50 to 100 times stronger than morphine and significantly more potent than heroin [00:15].

Lipid Solubility: How fentanyl’s ability to dissolve in fats allows it to cross the blood-brain barrier almost instantly, creating an immediate and overwhelming high [01:42].

Mu-Opioid Receptors: The specific way fentanyl binds to receptors in the brain to flood the system with dopamine [03:10].

The Deadly Margin of Error: How the "lethal dose" for fentanyl is so small it can fit on the tip of a pencil, leading to rapid respiratory depression [05:02].

Withdrawal and Dependence: Why the brain stops producing natural endorphins faster with fentanyl, leading to a more severe and rapid cycle of addiction [06:20].



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