How do clustered circulating tumor cells initiate metastasis?

Circulating tumor cell clusters may break off from a solid cancerous tissue and lead to metastatic dissemination. The Aceto Lab at ETH Zurich (www.theacetolab.com) investigates the biology and vulnerabilities of these clusters, aiming to identify novel therapeutic opportunities.
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Additional Information
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https://mhs.biol.ethz.ch/research/ace...
Aceto et al., Cell 2014 (https://pubmed.ncbi.nlm.nih.gov/25171...)
Gkountela et al., Cell 2019 (https://pubmed.ncbi.nlm.nih.gov/30633...)
Szczerba et al., Nature 2019 (https://pubmed.ncbi.nlm.nih.gov/30728...)
Donato et al, Cell Rep 2020 (https://pubmed.ncbi.nlm.nih.gov/32905...)
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