Скачать или смотреть Amlodipine Tablets VS Valsartan Tablet Which One Is Best Tablet For High Blood Pressure

Amlodipine Tablets VS Valsartan Tablet Which One Is Best Tablet For High Blood Pressure


Tablet Amlodopin VS Valsartan table detail review
Here's a detailed comparison review of Amlodipine vs Valsartan, two widely used antihypertensive medications. Both belong to different drug classes and have distinct mechanisms of action, benefits, and side effects.

Amlodipine vs Valsartan – Detailed Comparison
Feature Amlodipine Valsartan
Class Calcium Channel Blocker (Dihydropyridine type) Angiotensin II Receptor Blocker (ARB)
Mechanism of Action Inhibits calcium ion influx in vascular smooth muscle → vasodilation → lowers BP Blocks angiotensin II from binding to AT1 receptors → vasodilation + reduced aldosterone release
Primary Use Hypertension, Angina (chronic stable & variant), Coronary artery disease Hypertension, Heart failure, Post-myocardial infarction, Diabetic nephropathy (off-label)
Onset of Action 6–12 hours 2 hours (peak at 6 hours)
Duration of Effect 24–36 hours 24 hours
Typical Dose Range 2.5–10 mg once daily 80–320 mg once daily (may be split)
Effect on Heart Rate May cause reflex tachycardia No significant effect
Effect on Kidney Neutral Kidney protective (especially in diabetics)
Common Side Effects Edema (especially in ankles), headache, flushing, dizziness Dizziness, fatigue, hyperkalemia, hypotension
Serious Side Effects Rare: gingival hyperplasia, arrhythmia Rare: kidney dysfunction, angioedema (less than ACE inhibitors)
Use in Heart Failure Not preferred Yes, strongly recommended
Pregnancy Category Category C/D – Avoid in pregnancy Category D – Contraindicated
Drug Interactions Grapefruit juice (inhibits metabolism), CYP3A4 inhibitors NSAIDs (↑ renal risk), lithium, potassium supplements
Branded Forms Norvasc (Pfizer), generics widely available Diovan (Novartis), generics widely available

Combination Use
• Amlodipine + Valsartan (e.g., Exforge) is a common fixed-dose combination used in patients not controlled by a single agent.
o Synergistic effect: Amlodipine targets vascular smooth muscle; Valsartan addresses RAAS-mediated vasoconstriction.
o Reduced side effects: Valsartan can reduce amlodipine-induced peripheral edema.

When to Prefer One Over the Other
Scenario Preferred Drug
Isolated systolic hypertension Amlodipine
Hypertension + diabetes/CKD Valsartan
Hypertension + angina Amlodipine
Hypertension + heart failure or post-MI Valsartan
Edema-prone elderly Valsartan (or Amlodipine with caution)
Black patients (initial therapy) Amlodipine preferred
Combination therapy required Amlodipine + Valsartan (e.g., Exforge)

Final Thoughts
• Amlodipine is excellent for initial blood pressure control and angina, especially in elderly or Black patients.
• Valsartan is better for organ protection, especially in heart failure or diabetes.
• Many patients benefit from a combination of both, maximizing efficacy and minimizing side effects.


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