Psychiatry Pharmacogenomics: Depression 2010

Speaker: Vicki L. Ellingrod, Pharm.D., BCPP, FCCP

Presentation Outline:
1. Background
2. Pharmacodynamic Targets: Serotonin Transporter, Variable number of tandem repeats (VNTR), Serotonin-5HT1A receptor gene (HTR1A) , Serotonin-5HT2A receptor gene (HTR2A), Tryptophan Hydroxylase 1 (TPH1) , Tryptophan Hydroxylase 2 (TPH2), Monoamine Oxidase A (MAOA), G protein b-3 subunit, Growth Factors, Brain Derived Neurotrophic Factor (BDNF), Val66Met (rs6265)
3. Pharmacokinetic Targets: CYP2D6
4. Clinical Relevance
◦Efficacy: Response and Remission-Toxicity: Antidepressant Intolerance, SSRI-associated sexual dysfunction
◦Toxicity: Antidepressant Intolerance, SSRI-associated sexual dysfunction
5. Pharmacogenomics Testing Recommendations