Genetics and Vasculitis

0:00
3:24 Key questions: Is vasculitis “genetic”? What genetic testing should be sent?
9:28 Design of genetic studies.
10:26 Giant Cell Arteritis genetic study.
13:16 What do the results from this GCA genetic study tell us?
17:27 What is a genetic risk score?
20:59 Takeaways so far.
22:41 Vasculitis as a single gene disease.
24:52 DADA2
27:31 Takeaways
28:42 Vasculitis due to acquired mutations.
29:35 VEXAS
32:22 As we go through life our DNA acquires mutations.
35:06 Takeaways
37:15 Does vasculitis run in families?
42:08 Takeaways
43:20 What genetic testing should be sent?
45:45 Summary
47:48 Q: Where is most of this genetic research happening?
48:41 Q: My husband and his brother both have GPA. Should they be tested?
50:54 Q: Can DADA 2 be related to Factor V Lieden mutation?
51:54 Q: If you develop an autoimmune disease but do not have vasculitis but have a parent with vasculitis, does that autoimmune disease put you at higher risk of developing vasculitis?

Genetics and Vasculitis
Recorded December 2024