Скачать или смотреть NFL Picks - San Francisco 49ers vs Indianapolis Colts Prediction, 12/22/2025 Week 16 NFL Free Picks

NFL Picks - San Francisco 49ers vs Indianapolis Colts Prediction, 12/22/2025 Week 16 NFL Free Picks

Indianapolis Colts vs San Francisco 49ers 12/22/2025. The San Francisco 49ers travel to Indianapolis, IN to face the Indianapolis Colts at 8:15PM EST at Lucas Oil.

Doc's Sports provides NFL picks against the spread, expert predictions, betting tips and NFL odds on this matchup of Indianapolis Colts vs San Francisco 49ers.



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