AKT Signaling Pathway: Regulation by the Insulin Signaling Cascade

Lesson on the Insulin Signaling Pathway and its Regulation of the AKT Pathway. The insulin signaling cascade is activated upon binding of insulin to the insulin receptor. Afterwards, downstream targets, including IRS1/2, become activated, eventually leading to activation of AKT via two distinct mechanisms and two important phosphorylation sites on AKT. These AKT phosphorylation are important for AKT activation. These two sites also are regulated by two phosphatase enzymes as well. Eventually, activation of AKT will lead to particular effects within the insulin-stimulated cell, which we also discuss in this lesson.

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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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