Скачать или смотреть The Hair Loss Industry Is Broken | Evidence Quality Masterclass

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In the hair loss industry, the phrase “science-backed” no longer means anything.

Marketers have uncovered a repeatable formula to manipulate clinical trials – all by taking advantage of the broad legal definition of "hair loss" and "hair growth".

First, they design their studies in such a way to all but guarantees good results – and for any pill, supplement, topical, device, or shampoo they want to sell. They do this by:

-Starting a study in September to produce false-positive hair regrowth due to hair cycle seasonality

-Jam-packing people who just quit minoxidil into a placebo group, so they shed lots of hair

-Grouping vellus and terminal hairs together to force statistically significant hair count results

...and more.

The end-result: consumers buy these products, their "real-world" results almost never match the study's "clinical results", and then they blame themselves. In actuality, the blame should be shifted to the companies who knowingly engage in these practices – at the expense of consumers and to the benefit of their bottom line.

In this video, we’ll expose these practices.

We’ll feature dozens of examples from big brands – companies with study designs so deceptive that their "clinical findings" should not – in our opinion – be trusted.

Then, we’ll reveal a step-by-step framework you can employ to protect you from deceptive marketing practices: a framework for evaluating evidence quality.

With this framework, you'll be able to evaluate the real evidence on any hair growth product before you even buy it.

We hope this video helps you make better treatment choices, avoid bad product purchases, and save you years of wasted time, money, and hair.

If you want access to any of the studies or references in this video, here's our full write-up on the video: https://perfecthairhealth.com/evidenc...

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About Rob English:
-Editorial board member of Dermatology and Therapy
-Consumer advocate, medical editor specializing in hair loss disorders
-Peer-reviewed publications: https://perfecthairhealth.com/publica...

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00:00:00 –Intro: "Clinical Studied" = Meaningless
00:06:34 – Study Types: Nonclinical, Observational, Interventional
00:06:47 – 1. NONCLINICAL STUDIES (i.e., "MECHANISTIC")
00:07:10 – Example: Safety Testing A New Drug
00:07:59 – Problems: Poor Translatability To Humans
00:08:26 – Ex #1: Selenium + Vitamin E Supplements
00:09:10 – Ex #2: 18% Of Human Studies Contradict Mouse Studies
00:09:44 – Ex#3: Reishi Mushroom For Hair Growth (Reddit)
00:10:39 – Ex #4: Carbon 60 + Copper Peptides (Auxano Grow)
00:11:29 – 2. OBSERVATIONAL STUDIES (HUMAN)
00:12:18 – Ex: Genetic Mutations On Type II 5-Alpha Reductase
00:13:30 – Problems: Cannot Infer Causality
00:13:42 – Ex #1: Shark Attacks & Ice Cream Sales
00:14:16 – Ex #2: "Dairy Causes Hair Loss" (Pantene)
00:16:34 – 3. INTERVENTIONAL STUDIES (HUMAN)
00:17:30 – Hierarchy Of Evidence: A Tool To Predict Treatment Success
00:18:36 – Ex #1: MDhair
00:19:05 – 4. RANDOMIZED, BLINDED, CONTROLLED CLINICAL STUDIES
00:20:10 – RANDOMIZED
00:20:37 – Problems If Absent
00:20:49 – Example #1: L-Carnitine For Hair Growth (Oxford Biolabs)
00:23:34 – BLINDED
00:23:46 – Problems If Absent
00:23:47 – Ex #1 (Participants): Placebo Effect
00:24:11 – Ex #2 (Researchers): Biased Analysis (Multiple Sclerosis)
00:25:20 – CONTROLLED
00:26:04 – Ex: Setipiprant Study (PGD2)
00:26:19 – Problems If Absent
00:26:20 – Problem #1: Placebo Effect
00:27:12 – Ex: Scalp Massage Study
00:28:43 – Problem #2: Hair Cycle Seasonality
00:30:32 – Ex: Brotzu Lotion Study (Trinov)
00:31:26 – Summary (So Far)
00:31:38 – RANDOMIZED, BLINDED, CONTROLLED: PROBLEMS
00:32:35 – Problem #1: Participants Of Study ≠ Consumers Of Product
00:32:52 – Androgenic Alopecia (AGA) Vs. Telogen Effluvium (TE)
00:34:42 – Ex #1 & #2: Nutrafol & Viviscal
00:36:56 – Ex #3: Vitamin E
00:38:37 – Problem #2: Study Timeframes
00:38:42 – Hair Regrowth Takes Time Due To Hair Cycling
00:40:09 – Ex #1: ProCelinyl White Paper (Revela)
00:41:38 – Problem #3: Measurement Endpoints
00:41:56 – Hair Assessment Tools
00:43:32 – Issue #1: Subjective Endpoints Aren't Paired With Objective Endpoints
00:44:19 – Issue #2: Reporting Total Vs. Terminal Hair Count Changes
00:45:13 – Ex #1: Copper Peptides Study (ALAVAX)
00:46:00 – Problem #4: Product-Study Fit
00:46:18 – Issue #1: Product Studied ≠ Product Sold
00:46:21 – Ex #1: Laser Caps (Capillus)
00:47:07 – Issue #2: Ingredients On Label ≠ Ingredients Inside Product
00:47:17 – Ex #2: 80% Of OTC Products Fail Labeling Claims
00:47:55 – Issue #3: Product Delivery Vehicle ≠ Study Delivery Vehicle
00:48:11 – Ex #3: Caffeine Shampoo (Alpecin)
00:49:18 – Final Thoughts