Скачать или смотреть Thymosin Alpha for Recurrent Miscarriage: A Targeted Scientific Approach! | Dr Jay Mehta, Mumbai

Hi, I’m Dr Jay Mehta & In this video, I’ll explain how Thymosin Alpha plays a critical role in reproductive immunology, especially in patients with repeated IVF failures or multiple abortions.
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Video Flow
0:00 – Introduction
0:41 – Drug mechanism and application in IVF/abortions
1:19 – Essential preconditions: normal pelvis and tested embryo
1:58 – Genetic causes must be ruled out before use
2:37 – Diagnostic testing: BCL6, uNK cells, IL-8
3:18 – Protocol followed in India: dose, frequency, cost
4:01 – Duration of therapy and reasons for early stop
4:38 – Post-endometriosis use and hospital case series
5:18 – Conclusion
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Thymosin Alpha for Recurrent Miscarriage: A Targeted Scientific Approach! | Dr Jay Mehta, Mumbai

This is not a routine prescription. It’s a targeted therapy that only makes sense when your pelvis is normal, your embryo is tested, and all basic factors are ruled out. Let’s understand how to use this drug scientifically, not emotionally.

What is Thymosin Alpha?
Thymosin Alpha is a naturally occurring protein in the body that helps modulate immunity. It is not a hormone, and it doesn't work like steroids or antibiotics. It activates immune cells, especially T-cells, to enhance the body's response against infections and regulate overactive immunity.
In reproductive medicine, we don’t use it to boost general health. We use it to balance the uterine immune environment, especially when implantation fails despite good embryos.

When Do We Consider Thymosin Alpha?
Not every patient qualifies.
I use this drug only in high-risk cases, especially:
More than 2 IVF failures
More than 3–4 abortions
Documented implantation failure
Confirmed absence of genetic causes

That last point is critical. If genetic issues are causing abortion, no immunomodulator, including thymosin, will help.
Basic Criteria Before Starting Thymosin
I don’t begin thymosin until these conditions are met:
Pelvis must be normal – No endometriosis, no fibroids, no polyps, and no adenomyosis

Embryo should be euploid – Ideally genetically tested (PGT-A recommended)
Basic diagnostics must be done – This includes a detailed uterine biopsy
Only if all these are satisfied do I proceed.

Diagnostic Flow Before Starting Treatment
We start by diagnosing the cause of failure, not jumping into therapy.
A uterine biopsy helps us measure:
BCL-6 expression
Uterine Natural Killer (uNK) cells
M1 vs. M2 macrophage ratio and Interleukin-8 levels

This gives us a precise view of how active or overactive the immune system is in the uterus. Based on these results, I decide whether to include thymosin.

Current Protocol for Thymosin Alpha
There’s no universal protocol for thymosin yet. But based on hospital experience, I follow this:
Dose: Thymosin Alpha is administered 3 times a week
Start time: Usually in the pre-embryo transfer phase
Duration: Continued until 9–10 weeks of pregnancy
Cost: Approximately ₹5,000 per week

The reason we stop at 10 weeks is financial practicality. We don’t yet know if continuing beyond that helps, and for Indian patients, affordability matters.

When We Use It Post-Endometriosis Surgery
This is another important area.
If a patient has endometriosis, especially after surgery for peritoneal endometriosis, I sometimes continue thymosin post-op. In our hospital, we’ve followed over 700 such cases. Our results suggest a drop in recurrence rates over a 12-month follow-up window. This data is currently under review for publication.
It’s still early to call it a definitive solution, but I’ve seen promising responses.

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About Dr Jay Mehta & Shree IVF Clinic

Dr Jay Mehta is the Scientific Director of Shree IVF Clinic, a Luxury Facility for Advanced Assisted Reproduction and Advanced Pelvic Surgery in Mumbai. He is a very well-known Fertility Specialist and is one of the few specialists in the country who is also an extremely sound Embryologist and Andrologist.

For Online or Clinical Appointments, call us at +917738155558

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