Скачать или смотреть Moving away from a "trigger" (hit-and-run) model for inflammatory disease

Here I talk about the pathogen-trigger model for chronic inflammatory disease (sometimes called a hit-and-run model). I explain that I don't support a "trigger" model because, as a microbiologist, I cannot understand a mechanism by which a pathogen can "trigger" a life-long illness. Also, a "trigger" model heralds from an era where the body was considered sterile (before we knew there was a human microbiome). Instead, I present evidence that pathogens driving chronic inflammatory symptoms PERSIST as members of a person's microbiome ecosystems. By persisting in the body they can drive chronic disease via clear mechanisms: they induce chronic inflammation, antibody production, and dysregulate host gene expression. This is especially true of pathogens able to persist inside cells of the human immune system. I emphasize that we need improved laboratory/molecular tests to identify these persistent pathogens. We also need to search for persistent pathogens in areas of the body not usually included in common testing protocols.

I reference the following studies:

1. Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys:

https://www.ncbi.nlm.nih.gov/pubmed/2...

2. Ebola Virus Ribonucleic Acid Detection in Semen More Than Two Years After Resolution of Acute Ebola Virus Infection

https://academic.oup.com/ofid/article...

3. Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease:

https://www.ncbi.nlm.nih.gov/pmc/arti...