Скачать или смотреть The Brain’s Dark Matter: Exploring the Extracellular Matrix | Prof. Jessica Kwok

In our 25th episode, we're highlighting a fascinating and often overlooked area of neuroscience: the extracellular matrix of the brain. We are delighted to host Dr. Jessica Kwok, Associate Professor of Neuroscience at the University of Leeds, whose research is reshaping our understanding of memory, brain plasticity, and post-injury recovery.
In this episode, you will learn:
-What perineuronal nets (PNNs) are and their influence on brain function.
-The surprising role of the ECM in spinal cord injury recovery.
-How the ECM shapes brain development and aging.
-The reasons why some neurons possess PNNs while others do not.
-The therapeutic potential of targeting PNNs, and many more interesting topics!

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#Neuroscience #ExtracellularMatrix #SpinalCordInjury #ECM #PNN

This podcast is supported by the International Max Planck Research School for Neurosciences in #Göttingen, the European Neuroscience Institute, the Cluster of Excellence "Multiscale Bioimaging" in Göttingen, as well as, SFB1286.

Neuroscience and Beyond team:
Svilen Georgiev
Kristina Jevdokimenko
Ahsen Konaç Sayıcı
Beatriz Apgaua
Mels Akhmetali

Timestamps
00:00:00 - 00:01:40: Introduction
00:01:50 - 00:02:45: Dr. Jessica Kwok
00:02:45 - 00:06:00: What is the Extracellular Matrix (ECM)?
00:06:50 - 00:14:00: Historical Perspective on ECM & Perineuronal Nets (PNNs)
00:14:00 - 00:19:40: ECM's Role in Neurodevelopment and Aging
00:19:40 - 00:21:50: ECM Components in Different Brain Regions
00:21:50 - 00:24:40: The Role of ECM in Spinal Cord Injury
00:24:40 - 00:29:10: Major ECM Components
00:29:10 - 00:32:10: Trafficking of ECM Molecules
00:32:10 - 00:34:05: Functions of PNN/ECM
00:34:05 - 00:36:40: Why Do Some Cells Have PNNs, and Others Don't?
00:36:40 - 00:39:20: Hibernating Animals and PNNs
00:39:20 - 00:43:30: Studying PNN Components
00:43:30 - 00:51:40: Difference in Scientific Culture: East vs. West
00:51:40 - 00:57:40: Clinical Trials & Animal Tests
00:57:40 - 00:59:00: PNNs in Alzheimer’s Disease
00:59:00 - 01:00:30: Studying ECM: Why and How?
01:00:30 - 01:03:50: Exciting Discoveries in ECM Research
01:03:50: Concluding Remarks

References:
https://neural.leeds.ac.uk/news/modif...
https://www.mdpi.com/1422-0067/22/5/2434
https://cambridgeblog.org/2015/12/5-f...
Choanoflagellates research group: https://www.uib.no/en/michaelsarscent...