Скачать или смотреть Monitoring Tumor Microenvironment Immunotherapeutic Impact in Heterogeneous Cancer: Prostate Cancer,

Presented By: Eugene Shenderov, MD, DPhil, FACP

Speaker Biography: Eugene Shenderov was born in Chernivtsi, Ukraine and moved to Brooklyn, NY at the age of 5. During high school and college, he had the opportunity to conduct research in Dr. Alan Houghton’s laboratory at Memorial Sloan-Kettering Cancer Center, which inspired him to become a physician-scientist. He attended the B.A./M.D. program at Brooklyn College of the City University of New York where he graduated valedictorian and was awarded a Rhodes scholarship.

Webinar: Monitoring Tumor Microenvironment Immunotherapeutic Impact in Heterogeneous Cancer: Prostate Cancer, Spatial Transcriptomics, and a Novel Therapeutic Target B7-H3

Webinar Abstract: Background: Localized prostate cancer is notable for tumor heterogeneity, and immune heterogeneity within tumor versus benign areas. B7-H3, a member of the B7 superfamily, is highly expressed (relative to PD-L1 and PD-L2) in prostate cancer, and is associated with rapid biochemical recurrence, early metastases, and differential expression between tumor and benign prostate tissue. Methods: Enoblituzumab (MacroGenics, Inc.) is an investigational humanized Fc-optimized B7-H3–targeting antibody that induces antibody-dependent cellular cytotoxicity (ADCC). Recently, in a Phase 2 single-arm neoadjuvant trial (NCT02923180) at JHMI, men with operable intermediate- and high-risk localized prostate cancer received enoblituzumab (15 mg/kg IV weekly x 6) prior to surgery. Prostate glands were harvested 2 weeks after the last enoblituzumab dose, and were examined for pathologic and immunologic endpoints. The co-primary outcomes were safety and PSA0 at 1 year post-op.

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