Скачать или смотреть Lecture On Plasma Proteins(Albumin, Globulin) & Erythropoiesis: Stages, Sites, and Regulation | MBBS

An essential and detailed lecture for medical students (MBBS, BDS, etc.) covering two critical topics in Hematology: the types and functions of Plasma Proteins and the complete process of Red Blood Cell (RBC) formation (Erythropoiesis). The class thoroughly explains the stages of RBC maturation, the role of Erythropoietin, and the hormonal regulation of blood cell production.

Key Topics and Time-stamped Chapters (Use these for quick navigation):
Time Topic
[00:00] Introduction: Normal Reference Values for Blood Cells (RBC, WBC, Platelets) & Hemoglobin.
[01:56] Blood Composition: Plasma vs. Formed Elements (Hematocrit/PCV).
[03:08] Why the term "Formed Elements" is used (Platelets as cellular fragments).
[05:32] Functions of Blood (Transport, Immunity, Coagulation, Homeostasis).
[06:01] Plasma Proteins: Concentration, Units, and Site of Origin (Liver, Lymphocytes).
[08:08] Major Plasma Proteins: Albumin (most abundant), Globulin, and Fibrinogen.
[09:15] Albumin-Globulin (A/G) Ratio and its clinical significance (Reversed A/G Ratio).
[09:56] Globulin Subtypes: Alpha, Beta, and Gamma Globulins (Immunoglobulins).
[11:15] Clinical States: Hypoproteinemia and Hyperproteinemia (Causes like dehydration, burns).
[13:39] Functions of Plasma Proteins: Maintenance of Colloidal Osmotic Pressure.
[15:25] Plasma Proteins in Acid-Base Balance (Buffering Action) and Coagulation.
[16:15] Acute Phase Proteins and Transport Functions (Transferrin, Ceruloplasmin).
[21:35] Introduction to Hematopoiesis (Blood Cell Generation).
[21:54] Stem Cells: Totipotent, Pluripotent, and Multipotent (Hierarchy of potency).
[28:05] Erythropoiesis (RBC Formation) - Sites in Embryonic, Fetal, and Adult Life.
[28:35] Stages: Yolk Sac (Intravascular), Liver/Spleen (Hepatic/Extravascular), Bone Marrow.
[32:38] Hematopoietic Lineages: Common Myeloid Progenitor (CMP) vs. Common Lymphoid Progenitor (CLP).
[37:25] Stages of Erythropoiesis (Pro-Erythroblast, Basophilic, Polychromatophilic, Orthochromatic).
[38:20] Role of Erythropoietin (EPO) in early maturation.
[39:26] Key Event 1: Nucleus Extrusion at Orthochromatic/Late Normoblast stage.
[40:37] Key Event 2: Loss of Organelles (Mitochondria/Ribosomes).
[44:57] Factors Influencing Erythropoiesis Regulation.
[45:04] Primary Stimulus: Hypoxia (Decreased oxygen at tissue level).
[45:34] Erythropoietin (EPO) Synthesis in Kidney (Hypoxia-Inducible Factor - HIF).
[46:33] Negative Feedback of Oxygen on EPO secretion.
[49:00] Hormonal Influences: Androgens (stimulatory), Estrogen (inhibitory), Thyroxine.
[52:19] Maturation Factors: Vitamin B12, Folic Acid, and Castle's Intrinsic Factor.


SANTINIKETAN MEDICAL COLLEGE & HOSPITAL
Real Classroom Demonstration/Lecture
On: PHYSIOLOGY by Dr. Akash Ghosh Roy
(MBBS Batch: 2025-26)
Conducted on: 03-12-25