Скачать или смотреть CHAPTER 43 - Histamine, Bradykinin and Their Antagonists: Kallikrein-Kinin System Pharmacology

GOODMAN GILMAN PHARMACOLOGY
CHAPTER 43

This provides an overview of histamine, bradykinin, and their respective antagonists, crucial components of the human physiological and pathophysiological landscape. It explains histamine's biosynthesis, distribution, receptor types (H1-H4), and roles in allergic reactions, gastric acid secretion, and the central nervous system. This further details H1 receptor antagonists, categorising them by generation and discussing their therapeutic uses for allergies, motion sickness, and insomnia, alongside their pharmacological properties and adverse effects. Similarly, it introduces bradykinin and kallidin, outlining their formation within the kallikrein-kinin system, their physiological impact on the cardiovascular system and kidneys, and their pathological involvement in conditions like angioedema and pain. Finally, this examines drugs that modulate the kallikrein-kinin system, including kallikrein inhibitors and kinin receptor antagonists, highlighting their therapeutic applications, particularly in managing hereditary angioedema.