Скачать или смотреть Professor Michael Foley "Human therapies inspired by sharks"

Monoclonal antibodies have become an important class of therapies for a wide range of human conditions. Recently, an unusual new class of antibody-like proteins from sharks and camelids (llamas and alpacas) have made their way into the clinic. These antibody-like molecules are unusual in that they are very small (less than 1/10th the size of a human antibody) and they are extremely stable and easier to manufacture. Several groups are exploring these peculiar molecules not only as important biochemical tools but also as therapies for diseases ranging from cancer to fibrosis. Over the years Micks lab has developed a "humanized" version of the shark antibody (called an i-body) which will maintain the advantages of these small proteins but will avoid being seen as foreign when administered to humans as therapy.