Скачать или смотреть Lecture On HCL Secretion, Parietal Cell: Control & Clinical Dangers of Long-Term PPIs | MBBS

This class from Santiniketan Medical College & Hospital offers a detailed, clinically-focused breakdown of the Parietal Cell, the Proton Pump (H+/K+ ATPase), and the mechanisms controlling HCL release. Crucially, the lecture exposes the clinical risks associated with commonly prescribed medications, explaining the dangerous phenomenon of Rebound Hypersecretion caused by long-term Proton Pump Inhibitor (PPI) usage.

Master this topic for your MBBS exams and clinical practice!

Lecture Outline & Key Topics (with Timestamps)
Use these timestamps to jump directly to the most critical sections for study and revision:

[00:29] Peptic Ulcer Disease & The Role of HCL: Introduction to hypersecretion as a main culprit.

[01:57] Restitution (Mucosal Repair): The critical role of stem cells and healthy cell migration in mucosal barrier maintenance.

[05:40] Layers of the Stomach: Understanding the mucosal damage that leads to ulceration and potentially perforation.

[07:17] HCL Formation: Mechanism in the Parietal Cell: A detailed breakdown of H+ and Cl- ion transport.

[10:01] The Proton Pump (H+/K+ ATPase): The key enzyme in acid secretion and the target of PPIs.

[11:17] Post-Meal Alkalinity: The Alkaline Tide: Explaining why the pH of blood and urine increases after a meal.

[13:46] Clinical Correlation: Potassium Loss in Vomiting: Understanding the risk of hypokalemia due to K+ recycling.

[16:11] Proton Pump Inhibitors (PPIs): How drugs like Pantoprazole and Omeprazole work.

[22:00] Neural Control (Vagus Nerve/Acetylcholine): The role of the vagus nerve acting via the M3 receptor.

[24:18] Hormonal Control: Gastrin's Role: Functions of Gastrin (secretion, motility, and trophic effect).

[25:42] ⚠️ The Danger of PPI Rebound Hypersecretion: Detailed explanation of the Gastrin-induced trophic effect and increased ulcer risk when stopping PPIs.

[30:17] Autocrine, Paracrine, and Endocrine Glands: Differentiating GI regulatory mechanisms.

[35:19] Chemical Control: Histamine & Somatostatin: The roles of H2 receptors (target of H2 blockers) and Somatostatin receptors (SSTR).

[42:10] Clinical Case: Recurrent Ulcer (Gastrinoma): Discussion of Zollinger-Ellison syndrome caused by Gastrin-releasing tumors.

[47:30] Gastrin Control: Stimulators and Inhibitors: Summary of factors influencing G-cell activity (Amino Acids, Epinephrine, H+, Somatostatin, GRP).


SANTINIKETAN MEDICAL COLLEGE & HOSPITAL
Real Classroom Demonstration/Lecture
On: PHYSIOLOGY by Prof. (Dr.) Subhasis Mukherjee
(MBBS Batch: 2025-26)
Conducted on: 24-11-25