Скачать или смотреть Alport Syndrome 🧬🩸 | Genetics, Clinical Triad & Diagnosis | USMLE Step 1 High-Yield Nephrology

📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr
📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:-   / drgbhanuprakash  
📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash

Alport Syndrome 🧬🩸 | Genetics, Clinical Triad & Diagnosis | USMLE Step 1 High-Yield Nephrology

Alport Syndrome is a high-yield genetic disorder tested on USMLE Step 1, presenting with the classic triad of hematuria, sensorineural hearing loss, and ocular abnormalities. It is the most common form of hereditary nephritis, typically caused by mutations in type IV collagen genes, especially COL4A5 on the X chromosome, making X-linked inheritance the most frequent pattern. Affected males often present early and progress to chronic kidney disease or ESRD, while female carriers may show only microscopic hematuria. The pathophysiology involves defective glomerular basement membranes, leading to progressive nephritic syndrome, along with cochlear and ocular basement membrane abnormalities. Key features include anterior lenticonus (a pathognomonic lens abnormality) and sensorineural hearing loss at high frequencies. Diagnosis involves urinalysis, kidney biopsy (showing basket-weave appearance on EM), skin biopsy for alpha-5 collagen staining, genetic testing, and audiometry. Management includes ACE inhibitors or ARBs to delay renal progression, supportive care for CKD, hearing aids, and kidney transplantation in end-stage cases. This video covers everything you need to identify, understand, and remember Alport Syndrome — from molecular genetics to clinical findings and histopathology — making it perfect for USMLE Step 1 prep and classroom mastery.

#AlportSyndrome #USMLEStep1 #NephrologyUSMLE #GeneticDisorders #HereditaryNephritis #COL4A5 #Hematuria #BasketWeaveGBM #AnteriorLenticonus #HearingLoss #MedicalStudents #HighYieldNephrology #Step1Prep #BoardExamPrep #RenalPathology #CollagenTypeIV #FMGEPrep #MBBSPhysiology #USMLEReview #NephriticSyndrome #BasementMembraneDisorders #medicalanimations #fmge #fmgevideos #rapidrevisionfmge #fmge2024 #mbbslectures #nationalexitexam #nationalexittest #neetpg #usmlepreparation #usmlestep1 #fmge #usmle #drgbhanuprakash #medicalstudents #medicalstudent #medicalcollege #neetpg2025 #usmleprep #usmlevideos #usmlestep1videos #medicalstudents #neetpgvideos #usmlestep2videos