Treating Philadelphia chromosome-positive (Ph ) ALL

Описание к видео Treating Philadelphia chromosome-positive (Ph ) ALL

Prof Ottman speaks with ecancer about the past and future management of Ph ALL.

He describes the impact of TKI therapy on prognosis, and how this has gone on to modulate chemotherapy regimens towards less intensive courses, but highlights the difficulty of treating relapsed patients.

Prof Ottman also highlights the GRAAPH-2005 trial as confirming indications and patients who respond strongly to allogeneic or autologous stem cell transplant, with age as a major disposing factor.

With this in mind, he considers a future in which 3rd generation TKIs, stem cell transplant and immunotherapy might offer a chemo-free treatment regimen for patients.

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