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🍊 Grapefruit Juice: Healthy Drink or Hidden Danger?

It’s loaded with vitamin C and antioxidants — but grapefruit juice can also cause serious drug interactions by interfering with how your body processes medications.

In this episode, we unpack the pharmacokinetics behind grapefruit juice’s surprising ability to inhibit intestinal CYP3A4 enzymes. Learn how this can lead to dangerously high levels of drugs like statins, antihypertensives, and immunosuppressants — even when taken at normal doses.

🎧 You’ll discover:
Why grapefruit juice alters drug metabolism
Which medications are most affected — and the degree of risk
What clinical guidelines say about grapefruit interactions

📄 Scientific References:
Abu Dayyih W, Al-Ani I, Hailat M, Alarman SM, Zakaraya Z, Assab MA, Alkhader E. Review of grapefruit juice-drugs interactions mediated by intestinal CYP3A4 inhibition. J Appl Pharm Sci. 2024;14(05):059–068. doi:10.7324/JAPS.2024.160197
Kiani J, Imam SZ. Medicinal importance of grapefruit juice and its interaction with various drugs. Nutr J. 2007;6:33. Published 2007 Oct 30. doi:10.1186/1475-2891-6-33

⚠️ Disclaimer: This content is for informational and educational purposes only. It does not constitute medical advice or replace professional healthcare consultation. Always speak with a qualified physician or pharmacist before making changes to your diet, supplements, or medication regimen.

💡 Note: This episode was created using Google’s NotebookLM and includes summaries of peer-reviewed scientific research. The views expressed do not necessarily reflect those of the study authors or their institutions.

🎙️ Perfect for clinicians, pharmacists, researchers, and informed listeners who care about science and safety.

#HealthScience #DrugInteractions #CYP3A4 #Pharmacology #GrapefruitEffect #ClinicalPharmacy #EvidenceBased