Скачать или смотреть Kinase Signaling, Lipids, & Molecular Mechanisms - The Bhattacharyya Lab at Yale School of Medicine

For more information on Moitrayee Bhattacharyya or #YaleSchoolOfMedicine, visit: https://medicine.yale.edu/profile/moi... and www.bhattacharyya-lab.org.

With the advances in genomic technologies and structural tools, The Bhattacharyya Lab is increasingly learning about the identity and structural organizations of individual proteins that play a critical role in cellular signal transduction. These proteins usually work in an organized, interdependent macromolecular network. The next set of challenges are to: (1) understand the proteins in this network in terms of their composition, post-translational modifications (PTMs) and stoichiometry with spatiotemporal resolution, (2) understand the regulatory role of kinases and phosphatases within these networks, (3) understand the role of lipid microenvironment in dictating the assembly and function of proteins, (4) determine how physico-chemical perturbations, such as oxidative/chemotoxic stress and aging, affect proteins in this network, and (5) probe how proteins in this molecular network are altered in disease states. The Bhattacharyya Lab aims to answer some of these outstanding molecular questions in the context of learning and memory, and cognitive impairments in Down Syndrome.

0:00 The Bhattacharyya Lab
0:59 What are they studying?
1:09 How are they studying it?
2:05 Where might this research lead?