Скачать или смотреть liberal use of oxygen in critically ill patients... not such a good idea

Oxygen therapy was first described for the treatment of pneumonia in 1885. Since then, oxygen has been increasingly administered to acutely ill patients, with studies finding that 34% of patients in ambulances, 23% of those in emergency departments, and 47% of those in cardiac care units received supplemental oxygen therapy. In these settings, studies have found that 50% to 84% of patients were exposed to hyperoxemia because of excessive oxygen. Although adequate oxygen therapy is essential for treating hypoxemia, excessive oxygen therapy can cause a number of problems, including inflammatory cytokine production, absorption atelectasis, acute lung injury, reduced cardiac output, cerebral and coronary vasoconstriction, and central nervous system toxicity. Therefore, it is important to understand the potential risks and benefits of oxygen therapy for acutely ill patients.

oxygen administration (near 100% O2)
This systematic review and meta-analysis found that liberal oxygen therapy was associated with an increased risk of mortality in the hospital, at 30-day follow-up, and at the longest follow-up. The authors noted that for every 1% increase in the pulse oximetry, there was a 25% increase in the relative risk of in hospital mortality and a 17% increase in the relative risk of mortality at longest follow-up. The mean number needed to harm resulting in one death with liberal oxygen therapy was 71. The authors also found that there was no difference in morbidity outcomes (eg, worsening disability after acute stroke, development of hospital-acquired infections). Although previous small studies have suggested that oxygen supplementation may improve outcomes in patients with acute stroke, the current meta-analysis provides stronger evidence suggesting no significant benefit in this group.