Cell-free DNA in Transplant Assessments

Cell-free DNA (cfDNA) is the term used to describe the small fragments of DNA that occur naturally and circulate in the blood stream. Advanced technology using cfDNA has improved testing and screening options for transplant recipients. Donor-derived cell-free DNA (dd-cfDNA) can assess the amount of cell-free DNA in an organ recipient’s blood that originates from the donor. Elevated levels of cfDNA in the recipient’s blood may signify an increase in cell death from kidney injury and/or rejection. Studies have shown that cfDNA testing is more sensitive and specific than serum creatinine and is able to detect acute rejection at an earlier stage. Join us to hear from genetic testing experts as they discuss cell-free DNA and its potential as a powerful biomarker in transplant assessments.

Presented on January 28, 2020 by Phil Gauthier, MD and Alexander Wiseman, MD.