Скачать или смотреть Electroconvulsiometer

Maximal electroshock-induced seizures (MES)

The tonic-clonic convulsions were induced by maximal electroshock using an electroconvulsiometer (INCO, Ambala, India) by passing an alternating electric current of 50 Hz and 150 mA for 0.2 seconds through ear clip electrodes. The animals were preliminarily screened and the mice which showed the extension of hind limb upon electric shock were included in the study. All the drugs and propylene glycol were administered one hour prior to induction of convulsion. The duration of tonic hind limb flexion (THLF), tonic hind limb extension (THLE), clonus and stupor were noted. The vehicle treated mice showed the characteristic extensor tonus. The abolition of extensor (tonic) phase in drug treated groups was taken as criteria for their anticonvulsant activity.