Seroxat Causes Suicide and Self Harm - GlaxoSmithKline's 'Study 329' (Paxil/Aropax)

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For the past few years, an effort has been under way by a pair of academics to retract a study about the Paxil antidepressant in the Journal of the American Academy of Child and Adolescent Psychiatry that concluded the GlaxoSmithKline pill was "generally well tolerated and effective for major depression in adolescents." Why? Since then, the 2001 paper has been discredited amid charges that primary and secondary outcomes were conflated, selective results were reported and ghostwriting was involved (see this).
The details became known more three years ago as documents emerged from investigations (look here) and lawsuits charging Glaxo hid various risks. By then, the FDA required Glaxo to place a Black Box warning about suicidality in youngsters and UK regulators recommended the drug not be given to those under 18 years of age. But by 2010, the paper had been cited in more than 200 other articles, many of which continued to point to the study as evidence that Paxil is effective in treating adolescent depression, according to BMJ.

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