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Find out more about lipid nanoparticles at https://www.merckgroup.com/en/researc...

Thanks to Merck for sponsoring this video as part of their #humanprogress campaign!


Chapters

00:00 Introduction
01:37 10. How they’re made
02:34 9. They protect their cargo
03:18 8. Delivering the package
04:30 7. New vaccines
06:41 6. Treating cancer
07:45 5. Treating allergies
08:54 4. Turning genes off
09:53 3. Gene therapy
11:04 2. Treating ageing
12:00 1. ???
13:02 Thanks, Merck!


Sources and further reading

‘A universal flu vaccine is possible: time for the government to make it’ https://www.forbes.com/sites/stevensa...
‘Better fat bubbles could power a new generation of mRNA vaccines’ https://www.science.org/content/artic...
A more detailed introduction to how nanoparticles are manufactured from the brilliant materials physicist Richard Jones http://www.softmachines.org/wordpress...
See also my previous video on how editing the APOE gene could reduce some people’s risk of dementia…including Chris Hemsworth’s!    • How gene editing could save Chris Hemsworth  

Estimate of the lives saved by the covid vaccines—20 million in the first year! https://www.gavi.org/vaccineswork/cov...
Great article on the development of lipid nanoparticles up to and including the covid vaccines, including development of a nanoparticle-delivered transthyretin amyloidosis treatment https://www.nature.com/articles/s4157...
‘Anderson’s group synthesized a combinatorial library of 1200 lipid-like materials’ https://www.jstage.jst.go.jp/article/...
Review on using RNA in lipid nanoparticles as drugs https://www.nature.com/articles/s4156...
eg, for gene editing with ‘zinc-finger nucleases’ https://www.cell.com/molecular-therap... and CRISPR https://www.cell.com/cell-reports/ful...
Review article: ‘The clinical progress of mRNA vaccines and immunotherapies’ https://www.nature.com/articles/s4158...
Inhibition of PCSK9 with RNA interference reduces cholesterol and cardiovascular risk https://www.ncbi.nlm.nih.gov/pmc/arti...


Credits

Lipid nanoparticle animations and thumbnail image copyright Merck KGaA, Darmstadt, Germany
CRISPR animation Creative Commons Attribution UC Berkeley    • New CRISPR-powered device detects genetic ...  


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