Microcytic Anemia: Overview & Thalassemias (Pathophysiology) | Sketchy Medical

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Blast back in time to the late 1200s to join Micro Polo in his exploration of microcytic anemia, characterized by an MCV less than 80 and low reticulocyte count. We cover key causes using the T.A.I.L.S. mnemonic: Thalassemia, Anemia of chronic disease, Iron deficiency, Lead poisoning, and Sideroblastic anemia. Learn about the genetic underpinnings of alpha and beta thalassemia, their geographic prevalence, and the clinical presentations from mild anemia to severe conditions like hemoglobin H disease and hydrops fetalis. We also discuss the distinctive features of beta thalassemia, including extramedullary hematopoiesis and iron overload.

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