Скачать или смотреть The most exciting REAL anti-ageing drugs

Find out more about real anti-aging drugs in my book, Ageless: The new science of getting older without getting old https://ageless.link/

Or watch more longevity videos in my playlist:    • Aging  


Chapters

00:00 Introduction
00:46 Rapamycin
02:34 Senolytics
04:49 Metformin
06:18 Taurine
07:24 Statins
09:54 Conclusion


Sources and further reading

If you want to know more about rapamycin, ‪@mkaeberlein‬’s video is a longer introduction to the science behind it    • Rapamycin is the gold standard for longevi...  
And, if you want to know much more about metformin (and a bunch of other cool longevity science), you might enjoy Nir Barzilai’s interview with ‪@TheProofWithSimonHill‬    • Slow Aging with a Pill? | Nir Barzilai, MD...  

Rapamycin
Review of the evidence for rapamycin, rapalogues and other mTOR inhibitors in humans https://www.sciencedirect.com/science...
Phase 2b and Phase 3 trials of rapamycin-like drugs for improving immunity in older people https://www.thelancet.com/journals/la...

Senolytics
2018 paper giving D+Q to old mice https://www.nature.com/articles/s4159...
A great overview of the dozens of companies currently working on senolytics https://www.nature.com/articles/s4158...

Metformin
Study showing people with diabetes taking metformin outlived ‘healthy’ controls https://dom-pubs.onlinelibrary.wiley....

Taurine
More information and links in my Twitter thread on the results   / 1667075657874939907  
The paper (sadly paywalled) https://www.science.org/doi/10.1126/s...

Statins
Effect of statins on all-cause mortality in adults: a systematic review and meta-analysis https://www.mdpi.com/2077-0383/11/19/...

General
A recent paper from the Interventions Testing Program (ITP), with an overview of its successes so far: ‘Six compounds have thus far produced significant extension of life span in ITP studies in 1 or both sexes: rapamycin, 17α-estradiol (17aE2), nordihydroguaiaretic acid (NDGA), Protandim, glycine, and acarbose.’ (This paper adds Canagliflozin to the list.) https://www.ncbi.nlm.nih.gov/pmc/arti...
Here’s the ITP paper on NR, a compound related to NMN and other NAD boosters often discussed by David Sinclair, Harvard professor and author of the book Lifespan https://onlinelibrary.wiley.com/doi/f...
Calculations for risk of diseases with age can be found at https://github.com/ajsteele/ageless

Oh and btw, I’m British so I normally spell it ‘ageing’ just in case anyone’s searching for ‘anti-ageing’. Some people call this field of science biogerontology, geroscience or longevity research.


Credits

Stent animation CC-BY BVM Medical https://commons.wikimedia.org/wiki/Fi...
Mice on a treadmill CC-BY Aderbal Aguiar    • Running mice in treadmill  
Atherosclerosis progression diagram CC-BY YitzhakNat https://commons.wikimedia.org/wiki/Fi...
Neutrophil diagram CC0 Mrmw https://commons.wikimedia.org/wiki/Fi...


And finally…

Follow me on Twitter   / statto  
Follow me on Instagram   / andrewjsteele  
Like my page on Facebook   / drandrewsteele  
Follow me on Mastodon https://mas.to/@statto
Read my book, Ageless: The new science of getting older without getting old https://ageless.link/