BF Webinar Amphiphilic polymers for membrane proteins

Membrane proteins play a vital role in cellular communication and the control of transport across the membrane, and are therefore key therapeutic targets for many human diseases. However, their location, tightly packed with many different proteins and lipids within the membrane, has historically made the task of studying them very challenging. The study of membrane protein structure and function has been made easier with the application of methodologies based on encapsulation in amphiphilic polymers, such as SMA, allowing membrane proteins to be purified and studied whilst maintaining their lipid environment.

At this webinar, Professor Tim Dafforn (University of Birmingham) outlines this breakthrough methodology and Professor Antoinette Killian (Utrecht University) talks the role of lipids in membrane protein solubilization by SMA: how do they affect solubilization, do they affect properties of the nanodiscs, and how can we use the SMA technology to learn about lipid/protein interactions?

This webinar is Chaired by Professor Lars Jeuken, University of Leeds.

Please note that an audio issue means that Tim's presentation has occasional breaks. We apologise for the inconvenience.

www.biochemistry.org/webinars