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Presentation Video – Carnegie Mellon University Biomedical Engineering Forum 2025

Title: Soft Robotic Origami Crawler for Targeted Drug Delivery
Presenting Author: Purujit P. Sana
Co-authors: Trisha Mondal, Nazmul Alam, Sumaiya A. Rubab, Alifa H. Chowdhury
Affiliation: Bangladesh University of Engineering and Technology (BUET)

Abstract:
Traditional chemotherapy often requires large systemic doses, leading to severe side effects such as hair loss, fatigue, and immune suppression. Targeted drug delivery in the gastrointestinal tract is especially challenging, where conventional robots often fail in narrow, dynamic environments.

In this project, we present a soft robotic origami crawler designed to deliver anticancer drugs directly to localized tumor sites in the GI tract or liver. Powered by an electromagnetic actuator and utilizing anisotropic friction feet, the crawler achieves uniaxial locomotion through cyclic compression and extension.

This system aims to reduce dosage, minimize toxicity, and enable safe exit from the body, providing a potential breakthrough in targeted cancer therapy.

This video was prepared for the 7th Carnegie Mellon Forum on Biomedical Engineering (September 19, 2025).