Скачать или смотреть Influence of Age, Sex, and Mitochondrial Haplotype on Gut Microbiome in Rats | Aging-US

Aging-US #published this #trending research paper on February 27, 2025, in Volume 17, Issue 2, entitled “Age, sex, and mitochondrial-haplotype influence gut microbiome composition and metabolites in a genetically diverse rat model" by researchers from the Department of Nutritional Sciences, College of Allied Health, University of Oklahoma Health Sciences, Oklahoma City, OK; Department of Microbiology and Immunology, College of Medicine, University of Oklahoma Health Sciences, Oklahoma City, OK; Environmental and Molecular Toxicology, College of Agricultural Sciences, Oregon State University, Corvallis, OR; Department of Nutritional Sciences, College of Education and Human Sciences, Oklahoma State University, Stillwater, OK; Department of Biology, College of Arts and Sciences, University of Alabama at Birmingham, Birmingham, AL; Department of Biochemistry and Physiology, College of Medicine, University of Oklahoma Health Sciences, Oklahoma City, OK; Oklahoma Center for GeroScience and Healthy Brain Aging, University of Oklahoma Health Sciences, Oklahoma City, OK; Oklahoma Veteran Affairs Medical Center, Oklahoma City, OK. ‪@UniversityofOklahoma‬ ‪@ouhealthcampus‬
#aging #gutmicrobiome #mitochondria #metabolomics #research #openaccess #openscience #peerreviewed #journal #publishing #meded

DOI - https://doi.org/10.18632/aging.206211

Corresponding author - Archana Unnikrishnan - [email protected]

Abstract

We evaluated the impact of sex and mitochondrial-haplotype on the age-related changes in the fecal gut microbiome of the genetically heterogeneous rodent model, the OKC-HETB/W rat. The age-related changes in the microbiome differed markedly between male and female rats. Five microbial species changed significantly with age in male rats compared to nine microbial species in female rats. Only three of these microbes changed with age in both male and female rats. The mitochondrial-haplotype of the rats also affected how aging altered the microbiome. Interestingly, most of the microbial species that changed significantly with age were mitochondrial-haplotype and sex specific, i.e., changing in one sex and not the other. We also discovered that sex and mitochondrial-haplotype significantly affected the age-related variations in content of fecal short-chain fatty acids and plasma metabolites that influence or are regulated by the microbiome, e.g., tryptophan derived metabolites and bile acids. This study demonstrates that the host’s sex plays a significant role in how the gut microbiome evolves with age, even within a genetically diverse background. Importantly, this is the first study to show that the mitochondrial-haplotype of a host impacts the age-related changes in the microbiome.

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Keywords - aging, gut microbiome, mitochondria, metabolomics

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

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