Скачать или смотреть Epidural Electrical Stimulation Enhances Norepinephrine Responses During Stress - Ronnie Aliwiye

Full Title: Epidural Electrical Stimulation Enhances Norepinephrine Responses During Orthostatic Stress

Abstract: This project investigates whether epidural electrical stimulation (EES) of the lower thoracic spinal cord (T10–T12) can enhance norepinephrine responses during orthostatic stress in individuals with high-level spinal cord injury (SCI). Blood pressure instability, particularly orthostatic hypotension, is one of the most severe and under-treated consequences of SCI. Defined as a sudden and dangerous drop in blood pressure upon sitting or standing, orthostatic hypotension can cause dizziness, fainting, and long-term cardiovascular complications, significantly affecting independence and quality of life. EES is a neuromodulation therapy that delivers targeted electrical pulses through electrodes implanted in the epidural space. In this study, stimulation at the T10–T12 region (rich in sympathetic neurons regulating blood pressure), was used to help restore autonomic function that is otherwise impaired after injury. The primary aim of this project is to determine whether EES enhances sympathetic activation, reflected by increases in circulating norepinephrine during postural stress. A secondary aim is to assess whether these biochemical responses correspond with improvements in blood pressure stability, thereby linking chemical and physiological outcomes. Establishing this connection is critical to understanding the mechanisms by which EES improves cardiovascular function. The intended outcome is to clarify the role of norepinephrine in mediating the benefits of spinal cord stimulation. By identifying this link, the study positions EES as a promising therapeutic strategy not only for motor recovery but also for addressing autonomic dysfunction and reducing health risks in people with SCI. This project takes an experimental format, combining clinical testing with biochemical analysis.