Скачать или смотреть Iron & health, part 2, pathophysiology, Fenton reaction, Haber Weiss reaction, oxidative stress

Excess iron is dangerous b/c redox cycling creates ROS, leading to hydroxyl radicals that cause lipid peroxidation damage to plasma membranes & mitochondrial membranes. Brain is especially vulnerable with it's ubiquitous PUFA's. Video explains role of Fenton reaction in generation of ROS. How to avoid excess Fe; pros and cons of donating blood; common health problems and diseases a/w iron overload. Hereditary hemochromatosis is a disease caused by increased absorption of iron. When persons eat a meat, they absorb more iron, and this often leads to health problems in middle age or the older years. Excess total body iron is a/w liver failure "cirrhosis," damage to pancreas beta cells "diabetes," pigmentation of skin "bronze diabetes," pituitary iron accumulation "secondary hypogonadism," joint accumulation "arthritis" with chondrocalcinosis. Other problems with excess iron include sperm damage, and heart disease.