PPIs Mnemonic for USMLE

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Proton pump inhibitors or PPIs for short are drugs that inhibit proton or acid production by your stomach. They do this specifically by blocking an ATPase pump that pumps acidic protons out of cells in exchange for bringing potassium into the cell. Reduction of stomach acid is useful in treating acid-mediated disorders like peptic ulcers or acid reflux. Side effects of using PPIs include increased fracture risk as a result of decreased GI calcium absorption, and increased susceptibility to infections. Lastly, PPIs inhibit CYP or cytochrome P450 enzymes, leading to a significant drug interaction risk.

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