Скачать или смотреть Lowering LDL… But Losing Muscle? The Data You Haven’t Seen

A large UK Biobank analysis found that long-term statin use is associated with accelerated declines in skeletal muscle strength and lean mass over time, raising important questions about risk–benefit trade-offs.

Link to study: https://bit.ly/statins-shrink-muscle

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----------------------------------------Show Notes-------------------------------------

0:00 Intro
0:20 Statins linked to declining muscle strength & function
1:02 Why muscle strength matters for longevity & metabolic health
2:03 Grip strength explained as a marker of whole-body strength
2:56 Key finding: 25% grip strength loss & 73% lean mass decline
3:47 Risk–benefit problem: lowering LDL vs damaging muscle
4:47 Statins, GLP-1 suppression, and increased diabetes risk
5:43 Statins vs aging: accelerated strength loss over time
6:37 Study figures: statin users vs never-users compared
7:19 Creatine’s role in strength, cognition, hydration, and mood
8:13 German vs Chinese creatine: purity & impurity differences
9:18 Study conclusion: accelerated muscle loss regardless of genetics
10:17 Athlete experiences: real-world strength loss on statins
11:16 Mechanism: HMG-CoA reductase, CoQ10, and mitochondrial energy
12:27 Broader harms: diabetes risk, muscle atrophy, mitochondrial dysfunction
13:21 Final takeaway: questions patients should ask their doctor