Скачать или смотреть 📍 Dissolution Test apparatus : Working, Mechanisms And Uses Of Tablet Dissolution Process.

📍 Dissolution Test apparatus : Working, Mechanisms And Uses Of Tablet Dissolution Process.

The tablet dissolution process is a crucial test used to measure the rate at which an active pharmaceutical ingredient (API) is released from a tablet and becomes available for absorption in the body. This process simulates the conditions of the gastrointestinal tract to ensure that the tablet will dissolve properly after ingestion, thereby allowing the API to exert its therapeutic effect.

The most common apparatus used for dissolution testing are the USP Apparatus 1 (Basket Type) and USP Apparatus 2 (Paddle Type). In Apparatus 1, the tablet is placed in a wire mesh basket that rotates in a dissolution medium, typically water or a simulated body fluid, at a controlled temperature of 37°C. In Apparatus 2, the tablet is placed at the bottom of a vessel containing the dissolution medium, and a paddle rotates above it, stirring the medium to facilitate dissolution.

The dissolution medium is sampled at specified intervals, and the amount of dissolved API is measured, usually using spectrophotometric or chromatographic methods. The results are used to determine if the tablet meets the required dissolution criteria, ensuring consistent drug release and therapeutic efficacy.


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