Скачать или смотреть Game-changing universal receptor system developed for highly customizable CAR T cell therapy

Description: Researchers from the University of Pittsburgh have developed a universal receptor system that enables T cells to recognize any cell surface target, allowing for highly customizable CAR T cell and other immunotherapies for cancer and other diseases. By adding a SNAPtag enzyme to T cell receptors, different types or doses of cancer-targeting antibodies can be used to tailor treatments for optimal immune responses, potentially extending to solid tumors and offering hope to more patients.

image credit-Scientists have developed a universal receptor system for T cells that could lead to highly customizable CAR T cell and other immunotherapies for treating cancer and various diseases. The new approach involves engineering T cells with receptors containing a universal “SNAPtag” that can fuse with antibodies targeting different proteins. This allows treatments to be tailored for optimal immune responses. The researchers demonstrated the potential of their SNAP approach in CAR and SynNotch receptors, opening up possibilities for customized therapies in cancer, autoimmune disorders, and organ transplantation tolerance.


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