एंटीबायोटिक | Monocef Antibiotics | Monocef Injection Uses, Dose, Side Effects | Typhoid, UTI
💉 Monocef 1g Injection – Full Description
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🔹 Generic Name:
Ceftriaxone
🔹 Brand Name:
Monocef (by Aristo Pharma and others)
🔹 Dosage Form:
Injection (1 gram) – for intravenous (IV) or intramuscular (IM) use
🔹 Drug Class:
Third-generation cephalosporin antibiotic
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🧬 Mechanism of Action:
Monocef (Ceftriaxone) works by:
Inhibiting bacterial cell wall synthesis
Binds to penicillin-binding proteins (PBPs)
Causes cell lysis and bacterial death
➡️ Bactericidal effect
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✅ Uses (Indications):
1. Pneumonia and respiratory tract infections
2. Urinary tract infections (UTI)
3. Skin and soft tissue infections
4. Typhoid fever
5. Meningitis
6. Gonorrhea
7. Bone and joint infections
8. Pelvic inflammatory disease
9. Intra-abdominal infections
10. Sepsis / blood infections
11. ENT infections (sinusitis, otitis)
12. Surgical prophylaxis (infection prevention before surgery)
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⚠️ Contraindications:
1. Allergy to ceftriaxone or other cephalosporins
2. Neonates with jaundice (risk of kernicterus)
3. Concurrent use with IV calcium (especially in neonates)
4. History of severe penicillin allergy
5. Previous hemolytic anemia due to ceftriaxone
6. Caution in gallbladder disease
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🚺 Use in Pregnancy:
FDA Category B – Safe in pregnancy when prescribed
Avoid unnecessary use in 1st trimester
Can be used in infections during pregnancy with doctor's advice
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🤱 Use in Breastfeeding:
Passes in small amounts into breast milk
Generally considered safe during breastfeeding
Monitor baby for diarrhea or rash
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💉 Dosage (General Guide – Doctor Will Adjust Individually):
Condition Dosage Range
Adults (general) 1–2 g IV/IM once daily or divided dose
Severe infections Up to 4 g/day
Children 50–100 mg/kg/day (max 4 g)
Meningitis Higher doses needed (up to 2g IV every 12 hr)
Gonorrhea (single dose) 250–500 mg IM once
Typhoid fever 1–2 g/day for 7–14 days
🔸 Route: IM or IV injection
🔸 Duration: Depends on infection type (usually 5–14 days)
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⚠️ Side Effects (Top 10):
1. Pain at injection site
2. Diarrhea
3. Rash / itching
4. Nausea / vomiting
5. Fever
6. Headache
7. Raised liver enzymes
8. Vaginal yeast infection
9. Allergic reaction (mild to severe)
10. Gallbladder sludge (in children)
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🔗 Drug Interactions:
Calcium IV solutions (in neonates) – dangerous precipitation
Other antibiotics – avoid mixing unless prescribed
May interfere with some lab tests (glucose in urine)
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📝 Precautions:
Test for cephalosporin/penicillin allergy before use
Monitor kidney and liver function in long-term use
Use with caution in infants, elderly, and renal impairment patients
Complete the full course to avoid resistance
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📦 Storage:
Store dry powder at room temperature
Reconstitute only with prescribed sterile water/saline before use
Use immediately after reconstitution or as advised
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🧠 Quick Summary:
Parameter Details
Generic name Ceftriaxone
Brand name Monocef
Dose form Injection (1g)
Used for Bacterial infections (broad range)
Safe in pregnancy Yes (Category B)
Route IV or IM
Action Bactericidal
Major risks Allergy, diarrhea, gallbladder issues
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