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Dungeon Defenders 2 in 2024 is...

BUILD SPEEDFARM ONE HERO ONLY ( DRYAD ) :

Tree
Shard: Thick Vines / Vicious Strikes / Deadly Strikes
Mods: Defense Range / Anti-Melee / Anti-Chaos or Melee Boom

Nimbus
Shard: Fleeting Nature / Destruction / Mass Destruction
Mods: Defense Rate / Anti-Melee / Anti-Chaos or Melee-Boom

Bee
Shard: Defense Rate / Range Pylon / Destructive Pylon
Mods: Anti-Melee / Anti-Miniboss / Storm

Slime
Shard: Destruction / Mass Destruction / Vampiric Empowerment
Mods: Defense Rate / Anti-Orc / Anti-Chaos

NOTE : This build is optimize to speedfarm AFK, you can speedfarm any chaos (1-10) and speedfarm Onslaught floors, Incursion etc.. ( with decent gears and mods obviously ) The Tree is used to place your other defense and to do some area damage, like an Flame Aura but with way bigger range and no limit of target, the Nimbus does the main damage and clean everything ( mobs + flyers ) the Bee is used only to boost the other defense and to add CC ( Nimbus does water dmg and i use Storm mods on Bee ) useful for bosses, and the Slime is here to easily kill roller while you are AFK and to help with high density of mobs and bosses.
Don't forget to use a DPS pets with Tamer's Gambit shards and the Ring of ice to help killing mobs and bosses while you are AFK.