Скачать или смотреть Microbial fermentations optimization criteria

This tutorial explores the economic and underlying technical criteria to be considered when scaling-up and optimizing microbial fermentation.
Fermentation optimization relies on two major technical criteria: i) Fermentor productivity ProdP, defined as the annual mass of product produced, divided by the fermentor volume and the annual operating time. ii) Substrate conversion yield into product YP/S, defined as the annual mass of product produced divided by the annual mass of substrate consumed, particularly the sugar carbon source.
These two technical criteria directly determine the key economic criterion: the production cost per kilogram of product. Maximizing the substrate conversion yield reduces the material cost. Maximizing fermentor productivity reduces the equipment, energy, and labor costs per kilogram of product. Consequently, optimal fermentation operation requires balancing these two criteria to achieve the lowest overall production cost.