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MaxWell Biosystems - ISSCR 2022 Innovation Showcase

Title | Next-generation in-vitro assays: Characterizing the activity of human iPSC-derived neurons in 2D and 3D cultures at high resolution

Abstract | Both 2D and 3D brain models derived from human induced pluripotent stems cells (hiPSCs) are emerging as promising tools for investigating brain development and disease progression, as well as to test drug toxicity and efficacy in-vitro. In order to adopt hiPSC-derived 2D and 3D neuronal networks for rapid and cost-effective phenotype characterization and drug screening, it is necessary to assess their cell type composition, gene expression patterns, and physiological function.
In this innovation showcase, our invited speakers will showcase studies where MaxWell Biosystems’ advanced high-density microelectrode arrays (HD-MEAs) as the core of easy-to-use platforms, MaxOne (single-well) and MaxTwo (multi-well), allowed to capture neuronal activity across multiple scales, from sub-cellular to single cells, up to full networks and facilitated the characterization of the neuronal activity of hiPSC-derived neurons. During this session speakers will introduce how brain development disorders are modeled in 2D and 3D in vitro.
Overall, the presentations will provide an overview on how HD-MEA technology can efficiently advance research in 2D and 3D hiPSC-derived brain models and accelerate drug discovery for neurodegenerative diseases.