Summary: Stem cell transplants in older patients have, historically, had lower success rates than those in younger patients. This presentation describes several new promising strategies to improve transplant outcomes and survival rates in older patients.
Many thanks to Pharmacyclics, an AbbVie Company, and Janssen Biotech, Inc., Jazz Pharmaceuticals and Omeros Corporation, whose support, in part helped make this workshop possible.
Presenter: Uday Popat MD, The University of Texas MD Anderson Cancer Center
Meet the speaker: https://faculty.mdanderson.org/profil...
To read the transcript, go to: https://www.bmtinfonet.org/video/2022...
Highlights:
Older patients are most in need and are increasingly undergoing stem cell transplantation, but outcomes need to be improved.
Giving older patients high-dose chemotherapy given in smaller dosages over two-three weeks, instead of higher dosages in one week can improve outcomes.
A “pre-habilitation” program to improve older patients’ overall fitness and physiological reserve before transplant improves outcomes after transplant.
May 3, 2022 Part of the Virtual Celebrating a Second Chance at Life Symposium 2022
Presentation is 25 minutes long with 19 minutes of Q & A.
Key Points:
(04:10): How healthy a patient is – the physiological age - is more important than chronological age, when considering whether an older adult should consider a stem cell transplant.
(05:45): Since the median age for blood cancers is 68, it’s important to find effective ways to transplant older patients.
(06:19): The number of stem cell transplants performed in older patients is increasing.
(09:35): Older patients are most in need of transplant, are getting them more frequently, and their outcomes are getting better
(10:54): Older patients who have other health concerns, are not active, are unable to perform tasks of daily living and/or are unable to process information well have a poorer outcome after transplant than those who are fit.
(12:13): A promising strategy to improve outcomes in older adults is to give them high intensity chemotherapy before transplant over a longer period of time, like two to three weeks, rather than the standard one week
(16:41): Outcomes in older patients can also be improved by providing better supportive care to address other health issues associated with advanced age.
(18:29): Improving the fitness and nutritional status of older patients – their physiological reserve – before transplant can improve the outcome after transplant.
(19:48): A “prehabilitation program” was initiated at MD Anderson Cancer Center to improve the physical and functional status of older patients prior to transplant that involved a physical medicine and rehab physician, physical therapist, occupational therapist, dietitian, clinical pharmacist, advanced practice providers, nurses and geriatric doctors.
(22:42): Prehabilitation activities significantly improved survival rates in older patients.
WHO WE ARE: BMT InfoNet is dedicated to providing patients and their loved ones with emotional support and high quality, easy-to-understand information about blood stem cell transplants (bone marrow, peripheral blood and cord blood) and other cellular therapies. Whether you are just beginning your transplant or cellular therapy journey, or learning to manage the joys and challenges of survivorship,
BMT InfoNet is here to help before, during and after treatment. Our goal is to empower you with credible information and emotional support, so that you can take a more active role in decisions affecting your health. http://www.bmtinfonet.org
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