Aug 30 2024 This Week in Cardiology

From ESC: post-MI beta blockers, a new therapy for ATTR-CM, holding RASi before non-cardiac surgery, good news in HFpEF, and an ESC preview are the topics John Mandrola, MD, covers this week.


This podcast is intended for healthcare professionals only.


To read a partial transcript or to comment, visit:


https://www.medscape.com/twic


I. ABYSS


• ABYSS trial https://www.nejm.org/doi/full/10.1056...

• REDUCE AMI https://www.nejm.org/doi/full/10.1056...


II. ATTR -CM HELIOS B


Positive Top Line Results for Vutrisiran in Cardiac Amyloidosis


https://www.medscape.com/viewarticle/...


• HELIOS A https://www.tandfonline.com/doi/full/...

• HELIOS B https://www.nejm.org/doi/full/10.1056...


III. STOP or NOT Trial


• Observational Study Showing Benefits of Holding RASi https://doi.org/10.1097/ALN.000000000...

• STOP or NOT Protocol Paper -- https://trialsjournal.biomedcentral.c...

• JAMA STOP or NOT https://jamanetwork.com/journals/jama...


IV. GLP1a in HFpEF


The GLP-1 Agonist Semaglutide in HFpEF Cleared a Low Bar https://www.medscape.com/viewarticle/...


• STEP-HFpEF https://www.nejm.org/doi/full/10.1056...

• STEP-HFpEF-DM https://www.nejm.org/doi/full/10.1056...

• SELECT https://www.nejm.org/doi/full/10.1056...

• FLOW https://www.nejm.org/doi/full/10.1056...

• Lancet Meta-analysis https://doi.org/10.1016/S0140-6736(24...


V. ESC Preview


Mandrola's Five Big Trials to Look for at ESC 2024


https://www.medscape.com/viewarticle/...


Topline Finerenone Results Point to Advance in Heart Failure


https://www.medscape.com/viewarticle/...


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