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The brain and heart are intrinsically linked through a bidirectional relationship known as the "brain-heart axis"; a compromised state in one organ system often leads to complications in the other.

Interdependence: The brain depends on a constant flow of oxygen-rich blood, which the heart pumps throughout the circulatory system. The heart pumps about 20% of the body's blood supply to the brain.
Neurological Control of the Heart: The brain, particularly the insular cortex, regulates the autonomic nervous system which controls heart rate and blood pressure. Damage to specific brain regions can lead to heart dysfunction even in the absence of pre-existing heart disease.
Cardiac Influence on the Brain: Heart conditions can lead to structural changes in the brain over time, such as reduced gray matter density in areas related to memory and cognition (e.g., hippocampus and precuneus).

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