Culturing T Cells for Immune Cell Therapy

In this video, I outline how MAIT cells, which can be potentially used for immunotherapy, are able to retain their function while being expanded in culture from peripheral blood, and how they are able to be reprogrammed against specific targets.

This video summarises the paper: Expansion of donor-unrestricted MAIT cells with enhanced cytolytic function suitable for TCR redirection.

by: Tiphaine Parrot, Katie Healy, Caroline Boulouis, Michał J Sobkowiak, Edwin Leeansyah, Soo Aleman, Antonio Bertoletti, Margaret Sällberg Chen, Johan K Sandberg

This is a link to where you can find a copy of the article for yourself to read:
https://insight.jci.org/articles/view...

Sections:
0:00 Introduction
6:42 Importance
7:14 Expansion of donor-unrestricted MAITcells with enhanced cytolytic function suitable for TCR redirection.
7:40 Results
11:12 Summary
11:45 Significance
12:02 Future Directions

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