Molecular brain changes linked to APOE4 :Study

#alzheimerdisease #bloodbrainbarrier #neurons #geneticanalysis #endothelialcells #bloodvessels #pericytes #proteinanalysis

Recent research has revealed a lot about Alzheimer’s disease, but scientists have yet to paint a complete picture of how genetic risk for the illness causes brain damage that ultimately causes memory loss and cognitive decline.

A new study from the Keck School of Medicine, recently published in the Journal of Experimental Medicine documents, in real-time, that APOE4, the main susceptibility gene for Alzheimer’s disease, leads to molecular changes in the brain’s blood vessels, which are then followed by changes in the synapses that connect brain cells. The study also suggests potential targets in blood vessels for treatment early in the disease process - before cognitive decline occurs.

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