Introduction to Pharmacokinetics: ADME Overview | Pharmacology

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In this lecture EKG is going to cover an introduction to pharmacokinetics, looking at an overview of the four main processes, which are absorption, distribution, metabolism, and excretion.

We’ll also break down some key pharmacokinetic concepts, such as bioavailability, first-pass metabolism, and half-life, describe their clinical importance, and start seeing how we can calculate such parameters.

And then, in later pharmacokinetics lectures, we’re going to expand on these topics.

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Lecture Overview:
0:00 Intro
0:35 Pharmacodynamics vs Pharmacokinetics
2:03 Drug Absorption: Routes Of Administration, Factors Influencing Absorption & Mechanism
9:41 Bioavailability (F)
12:07 Oral vs Intravenous Administration
16:30 Drug Distribution: Factors Influencing Distribution & Specific Barriers
19:55 Drug Apparent Volumed Of Distribution (Vd)
22:00 Drug Elimination Overview
22:17 Drug Metabolism: Phase I & Phase II Reactions
29:30 Drug Excretion
30:50 Drug Dosage & Blood Levels
34:30 Half-Life & Clearance: Zero & First Order Kinetics
39:56 Pharmacokinetics Variability

✏️ All diagrams were made by EKG.
For educational purposes only; NOT medical or other advice.

Lecture Source:
Ritter, J., Flower, R.J., Henderson, G., Yoon Kong Loke and Rang, H.P. (2018). Rang and Dale’s Pharmacology. 9th ed. Endinburgh: Elsevier.
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