Still tired after 10 hours of sleep? Discover why your brain’s arousal circuits—not your pillow—are the real culprit behind relentless fatigue. In this follow-up to “Tired All the Time? Your Brain Might Be Trying to Tell You Something,” consultant psychiatrist Dr Sanil Rege walks you through the same clinical framework he uses to match treatment to each patient’s unique symptom stack.
#TiredAllTheTime, #BrainFog, #ChronicFatigue, #WiredAndTired, #SleepButStillTired, #Hyperarousal, #ADHDFatigue, #FatigueTreatment, #MesolimbicSystem, #PsychiatrySimplified
0:00 Why You’re Still Tired After “Enough” Sleep
1:18 Step 1: Rule-Outs in the Diagnostic Hierarchy (Iron, Thyroid, OSA, etc.)
2:59 Mesolimbic Salience Network & Hyper-Arousal Explained
4:30 The A-C-E Model: Activity • Cognition • Emotion
6:45 Allostatic Load – How a “Wired-and-Tired” Brain Burns Out
7:36 Lane 1: Calming the Alarm (Sleep & Salience-Network Reset)
8:56 Lane 2: Powering the Prefrontal Cortex (Dopamine/Noradrenaline Support)
10:32 Lane 3: Rebooting the Reward Circuit (Anhedonia & Motivation)
11:14 Lane 4: Healing Developmental Wiring (Safety & Meaning Work)
12:11 Turning Formulation into Targeted Treatment – Real-World Match-Ups
14:30 Key Takeaways, Next Steps, & Soft CTA to The Academy
What you’ll learn 🔍
• 4-lane model to calm hyper-alert circuits, power up the prefrontal cortex, reboot reward loops, and heal developmental wiring
• Why a “wired-and-tired” brain can feel exhausted yet overstimulated at the same time
• How the mesolimbic salience network and allostatic load fragment deep sleep
• Step-by-step diagnostic hierarchy—from ruling out iron, thyroid, and sleep-apnoea to pinpointing dopamine–noradrenaline dysregulation
• Real-world medication & therapy pairings: prazosin for nightmares, modafinil for brain fog, trauma-focused CBT for over-arousal
• Lifestyle levers that actually shift circuits: circadian anchoring, micro-goals, bright-light therapy, anti-inflammatory nutrition
Who’s this for?
• Anyone waking up exhausted despite “enough” sleep
• Clinicians seeking a circuit-based approach to fatigue, burnout, or ADHD-like inertia
• Learners who want practical neuroscience that translates directly to patient care
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#Neuroscience, #CognitiveFatigue, #WiredButTired, #ADHD, #PTSD, #SleepDisorders, #Dopamine, #Inflammation, #ChronicFatigue, #DrRege, #PsychiatrySimplified, #SleepArchitecture, #EmotionalExhaustion, #SurvivalMode, #BrainHealth
🧠 Related Resources: Neuropsychiatry of Sleep Course (Academy by Psych Scene) ➔ https://www.academy.psychscene.com/co...
📚 Read the full article: Neuropsychiatry of Sleep ➔ https://psychscenehub.com/psychinsigh...
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#ADHD #Sleep #PsychiatrySimplified #ADHDTreatment #SleepDisorders #Neuroscience #MentalHealth
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