Screening of Antihypertensive Agent | Goldblatt Method | 2 kidney 1 clip method

Screening of Antihypertensive Agent | Goldblatt Method | 2 kidney 1 clip method | Acute Renal Test

Renal Test
chronic kidney disease
kidney disease
kidney
two kidney goldblatt hypertension
renal disorders 1
chronic kidney disease stage 3
signs of kidney disease
first sign of kidney disease
early signs of kidney disease
screening
kidney failure
kidney disease diet
kidney disease treatment
kidney disease prevention
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HYPERTENSION
Hypertension is defined as a sustained increase in blood pressure of 140/90 mmHg or higher, a criterion that characterizes a group of patients whose risk of hypertension- related cardiovascular disease .

Goldblatt Method :- Goldblatt et.al (1934) Three variants of hypertension are produced by this method. 1. Two kidney one clip method(2K1C) 2. One kidney one clip method(1K1C) 3. Two kidney two clip method(2K2C)

Acute Renal Hypertension in Rats/2K1C Principle used : Ischemia of the kidneys causes elevation of blood pressure by activation of renin-angiotensin system. Clamping of renal artery for 4h Accumulated renin released into circulation after releasing the vessel Protease renin catalyses the first & rate limiting step in the formation of angiotensin2 Acute hypertension Vogel & Vogel, drug discovery and evaluation ,chapter A2, methods to induce experimental Hypertension,