Polycystic Kidney Disease : Internal medicine by Dr Rajesh Gubba

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Polycystic Kidney Disease : Internal medicine by Dr Rajesh Gubba

Polycystic kidney disease (PKD) is an inherited disorder in which multiple cysts develop in the kidneys. The WHO classification recognizes two distinct disorders: autosomal recessive PKD (ARPKD), which is associated with a short life expectancy that rarely surpasses childhood, and autosomal dominant PKD (ADPKD), which is associated with a reduced life expectancy in adulthood. The severity of symptoms varies significantly depending on the underlying disorder. Onset of ARPKD is usually in infancy or childhood, with patients presenting with pulmonary insufficiency and progressive renal failure. Patients with ADPKD, on the other hand, typically present with flank pain, arterial hypertension, and progressive kidney disease in adulthood. Early diagnosis and treatment may prevent or delay end stage renal disease. Kidney transplantation is the only curative treatment option.

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