Скачать или смотреть Convergent Pathology: How Autism and Alzheimer's Meet at the mTOR Pathway

Scientific research indicates a significant molecular link between *Autism Spectrum Disorder (ASD)* and *Alzheimer’s disease (AD)**, specifically through the **mTOR signaling pathway**. Studies using mouse models, such as those with **Shank3* and *Cntnap2* mutations, reveal that *hyperactive Akt-mTOR signaling* contributes to core deficits like impaired social interaction. By employing *SNOTRAP-based mass spectrometry**, researchers identified that **S-nitrosylation**, a protein modification driven by nitric oxide, targets key proteins shared by both conditions. Experimental evidence shows that pharmacological inhibitors like **rapamycin* can reversibly restore social behaviors in these models, though they may not affect hyperactivity or repetitive interests. Ultimately, these findings suggest that targeting the *mTOR pathway* offers a promising therapeutic strategy for treating diverse neurodevelopmental and neurodegenerative pathologies.